Philip W. Lavori
Publication Details
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Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report.
Am J Psychiatry. 2009; (5): 599-607
Phase III clinical trials for depression enroll participants with major depressive disorder according to stringent inclusion and exclusion criteria. These patients may not be representative of typical depressed patients seeking treatment. This analysis used data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project--which used broad inclusion and minimal exclusion criteria--to evaluate whether phase III clinical trials recruit representative depressed outpatients.
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