Susan Knox
Publication Details
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Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.
Clin Cancer Res. 2012; (12): 3366-76
Hypoxia is an important characteristic of the solid tumor microenvironment and constitutes a barrier for effective radiotherapy. Here, we studied the effects of darinaparsin (an arsenic cytotoxin) on survival and radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models, compared to effects on normal tissues.
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