Patrick O. Brown
Publication Details
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Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli.
Genome Biol. 2004; (11): R87
The chromosome of Escherichia coli is maintained in a negatively supercoiled state, and supercoiling levels are affected by growth phase and a variety of environmental stimuli. In turn, supercoiling influences local DNA structure and can affect gene expression. We used microarrays representing nearly the entire genome of Escherichia coli MG1655 to examine the dynamics of chromosome structure.
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