Cancer Institute– A national cancer institute
designated cancer center

Stefanie S. Jeffrey, MD

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Publication Details

  • Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.

    Ameri K, Luong R, Zhang H, Powell AA, Montgomery KD, Espinosa I, Bouley DM, Harris AL, Jeffrey SS. Br J Cancer. 2010; 102 (3): 561-9

    Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease progression. The aim of this study was to examine the as yet unknown relationship between hypoxia and CTCs.

    PubMedID: 20051957

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