Albert Koong
Publication Details
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Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.
PLoS One. 2009; (9): e7033
The unique metabolism of tumors was described many years ago by Otto Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial activity. However, "aerobic glycolysis" generates fewer ATP per glucose molecule than mitochondrial oxidative phosphorylation, so in terms of energy production, it is unclear how increasing a less efficient process provides tumors with a growth advantage.
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