Branimir I. Sikic, M. D.
Publication Details
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Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis.
J Natl Cancer Inst. 1994; (15): 1152-8
The major known mechanisms of resistance to etoposide include altered expression of its target enzyme, topoisomerase II (Topo II), and the multidrug-resistant phenotypes encoded by the mdr1 and MRP (multidrug resistance-associated protein) genes. There is little information regarding the distribution, frequency, and origin of these mechanisms in cancer cells.
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