Matthew Bogyo
Publication Details
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Friend or foe? Turning a host defense protein into a pathogen's accomplice.
Chem Biol. 2008; (9): 879-80
Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.
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