Cancer Institute A national cancer institute
designated cancer center

Department: Stanford Cancer Institute

Cancer Biology

  • Professor of Medicine (Hematology) and, by courtesy, of Chemical and Systems Biology
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Clinical Focus
    • Hematology
    • Medical Oncology
    Research Interest

    We explore angiogenesis, cancer genomics, intestinal stem cells, and hepatic glucose metabolism. Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. Intestinal stem cell projects use primary intestinal culture and mouse genetics to study injury-inducible vs homeostatic stem cells. We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery.

  • Professor of Pathology, Genetics and, by courtesy, of Biology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Clinical Focus
    • Pathology
    • Pathology and Laboratory Medicine
    Research Interest

    Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.

  • Assistant Professor of Molecular and Cellular Physiology
    Member, Stanford Cancer Institute
    Research Interest

    We study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.

  • Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine and Professor of Molecular and Cellular Physiology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.

  • Professor of Dermatology
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Clinical Focus
    • Cutaneous (Dermatologic) Oncology
    • Dermatology
    • Skin Cancer
    Research Interest

    Our lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.

  • Emma Pfeiffer Merner Professor in the Medical Sciences
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events. We also study how cells acquire cholesterol from the diet and from LDL.

  • Associate Professor of Pediatrics (Cancer Biology) and of Genetics
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Research Interest

    We are interested in the links between the basic cell cycle machinery and the factors controlling self-renewal, differentiation, and regeneration. In particular, we are intrigued by the differences and the similarities between "normal" cells, cancer cells, and stem cells. We investigate the mechanisms by which normal cells become tumor cells, and we aim to understand the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells.

  • Stanford W. Ascherman, MD, FACS, Professor in Genetics
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Member, Stanford Neurosciences Institute
    Research Interest

    Our laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states

  • Associate Professor of Biochemistry
    Member, Bio-X
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Research Interest

    We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.

  • Associate Professor of Urology
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Research Interest

    We focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.

  • Associate Professor (Research) of Pediatrics (Cancer Biology)
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Clinical Focus
    • Pediatric Hematology-Oncology
    • clinical genomics
    • pediatric sarcomas
    Research Interest

    Our laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer. Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels.

  • Klaus Bensch Professor in Experimental Pathology, Emerita
    Member, Stanford Cancer Institute
    Research Interest

    The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.

  • William M. Hume Professor in the School of Medicine, Professor of Structural Biology, of Molecular and Cellular Physiology and of Photon Science
    Member, Bio-X
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Research Interest

    Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the architecture and dynamics of intercellular adhesion junctions, the molecular basis of cell polarity, and the Wnt signaling pathway. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.

  • Professor of Neurosurgery
    Member, Stanford Cancer Institute
    Research Interest

    Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.

  • Associate Professor of Chemical and Systems Biology and of Developmental Biology
    Member, Stanford Cancer Institute
    Research Interest

    Research in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.

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