Department: Stanford Cancer Institute
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Academic Appointments Associate Professor - Med Center Line, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Thoracic Oncology
- Lung Cancer - Medical Oncology
- Investigational Therapeutics
Research InterestDr. Wakelee's research is focused on clinical trials in patients with lung cancer and other thoracic malignancies such as thymoma and thymic carcinoma. She also works with novel agents for all malignancies as part of the developmental therapeutics group of the cancer center. Other interests include translation projects in thoracic malignancies and collaborations with population scientists regarding lung cancer questions.
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Academic Appointments Member, Stanford Cancer Institute
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Academic Appointments Emeritus Faculty, Acad Council, Pathology
Member, Stanford Cancer Institute
Research InterestThe main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.
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Academic Appointments Professor - Med Center Line, Surgery - General Surgery
Member, Stanford Cancer Institute
Clinical Focus- Breast Cancer
- Breast Cancer > Breast Cancer Clinical Trials
- Breast Cancer
Research InterestClinical treatment trials in Breast Cancer, especially local recurrence of breast cancer. Dr. Wapnir is institutional Principal Investigator for National Surgical Adjuvant Breast and Bowel Project (NSABP). Laboratory research includes exploring the activity of breast iodide transporter in breast cancer. These endeavors have lead to translational research protocols.
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Academic Appointments Emeritus (Active) Professor, Pathology
Emeritus Faculty, Acad Council, Pathology
Member, Stanford Cancer Institute
Clinical Focus- Anatomic/Clinical Pathology
- Pathology and Laboratory Medicine
Research InterestThe research in my laboratory involves the application of monoclonal and polyclonal antibodies and a variety of immunohistochemical methods to study human B-cell, T-cell, accessory cell and related neoplasms.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Pediatrics - Stem Cell Transplantation
Member, Stanford Cancer Institute
Clinical Focus- Hematology, Pediatric
- Oncology (Cancer), Pediatric
- Pediatric Hematology-Oncology
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Structural Biology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Molecular & Cellular Physiology
Professor, Stanford Synchrotron Radiation Lightsource - SSRL
Research InterestOur laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the architecture and dynamics of intercellular adhesion junctions, the molecular basis of cell polarity, and the Wnt signaling pathway. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.
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Academic Appointments Professor, Pathology - Stem Cell Institute
Member, Bio-X
Member, Stanford Cancer Institute
Professor, Developmental Biology
Professor (By courtesy), Biology (School of Humanities and Sciences)
Research InterestStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
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Academic Appointments Professor - Med Center Line, Surgery - General Surgery
Member, Stanford Cancer Institute
Clinical Focus- GI Oncology
- Anal Cancer
- Basal / Squamous Cell Carcinomas
Research InterestClinical research focused on the diagnosis, prevention and treatment of anal cancer and its precursor lesions. Clinical trials of ablative therapy for High-grade Squamous Intraepithelial Lesions (HSIL) of the anus and perianal tissues as a means for preventing anal cancer. Basic science work in collaboration with Ronald Davis and Hanlee Ji focused on the molecular genetic and pathologic studies of anal cancers using moecular inversion probe genomic technology
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Natural Sciences Cluster - Chemistry
Member, Bio-X
Member, Stanford Cancer Institute
Professor (By courtesy), Chemical and Systems Biology
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Academic Appointments Assistant Professor - Med Center Line, Medicine - Blood & Marrow Transplantation
Member, Stanford Cancer Institute
Clinical Focus- Blood and Marrow Transplant
- Lymphoma
- Cutaneous T-Cell Lymphoma
Research InterestMy research interest is on immunotherapy (including allogeneic transplant) of cancer. I have studies the mechanism of monoclonal antibody therapy in lymphoma patients and am currently working on designing new strategy to enhance the clinical efficacy of antibody therapy by infusing expanded NK cells. I am also interested in using tumor vaccine along with hematopoietic cell transplant.
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Academic Appointments Member, Stanford Cancer Institute
Research Interest- Cancer etiology (diet, familial, genetic), especially breast, prostate and colon cancer - Cancer surveillance (Cancer registration, cancer patterns) - Cancer outcomes (Survival, quality of life, quality of care)
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Academic Appointments Professor, Health Research & Policy - Epidemiology
Member, Stanford Cancer Institute
Research InterestCancers of the prostate, breast and ovary account for a major proportion of new cancer cases and cancer deaths in the U.S. each year. Our recent research focus has been on developing improved statistical methods for the design and conduct of studies involving hereditary predisposition and modifiable lifestyle characteristics in the etiologies of site-specific cancers.
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Academic Appointments Member, Stanford Cancer Institute
Clinical Focus- Cardiothoracic Surgery
- Esophageal Cancer - Thoracic Surgery
- Heart and Lung Transplantation
Research Interestclinical lung and esophageal cancer treatment studies, lung transplantation, surgical ,management of emphysema.
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Academic Appointments Professor, Natural Sciences Cluster - Statistics
Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
Member, Bio-X
Professor (By courtesy), Biology (School of Humanities and Sciences)
Research InterestCurrent interest centers on the application of statistics to problems arsing from biology. We are particularly interested in questions concerning gene regulation and signal transduction.
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Academic Appointments Professor, Neurosurgery
Member, Stanford Cancer Institute
Research InterestOur goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.
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Academic Appointments Professor, Medicine - Cardiovascular Medicine
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Radiology
Clinical Focus- Congenital Heart Disease (Adult)
- Cardiovascular Disease
Research InterestMy lab works on biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging technologies to better understand stem cell biology in vitro and in vivo. For adult stem cells, we are interested in monitoring stem cell survival, proliferation, and differentiation. For ESC, we are currently studying their tumorigenicity, immunogenicity, and differentiation..
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Academic Appointments Associate Professor, Chemical and Systems Biology
Associate Professor, Developmental Biology
Member, Stanford Cancer Institute
Research InterestResearch in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.

