Department: Stanford Cancer Institute
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Academic Appointments Associate Professor, Pediatrics - Cancer Biology
Member, Child Health Research Institute
Member, Bio-X
Member, Stanford Cancer Institute
Associate Professor, Genetics
Research InterestWe are interested in the links between the basic cell cycle machinery and the factors controlling self-renewal, differentiation, and regeneration. In particular, we are intrigued by the differences and the similarities between "normal" cells, cancer cells, and stem cells. We investigate the mechanisms by which normal cells become tumor cells, and we aim to understand the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells.
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Academic Appointments Professor, Microbiology & Immunology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestOur laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.
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Academic Appointments Associate Professor, Biology (School of Humanities and Sciences)
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestMy laboratory has three major research efforts: 1) In vivo fluorescence imaging and behavioral studies of cerebellar-dependent motor control and motor learning. 2) Development and application of fiber-optic fluorescence microendoscopy imaging techniques for studies of learning and memory in behaving mice and for clinical uses in humans. 3) Development of high-throughput, massively parallel imaging techniques for studying brain function in large numbers of Drosophila concurrently.
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Academic Appointments Professor Emeritus, Medicine - Hematology
Emeritus Faculty, Acad Council, Medicine - Hematology
Member, Stanford Cancer Institute
Clinical Focus- Hematology
- Hematology > Leukemia - Acute and Chronic
- Hematology
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Academic Appointments Professor - Med Center Line, Pathology
Member, Stanford Cancer Institute
Professor - Med Center Line (By courtesy), Pediatrics - Medical Genetics
Clinical Focus- Pathology and Laboratory Medicine
- Clinical Pathology
Research InterestIris Schrijver is a diplomate of the ABMG, with specialty certification in Clinical Molecular Genetics. In addition, she is a diplomate of the ABP in Clinical Pathology. She is one of the directors of the diagnostic Molecular Pathology laboratory and Stanford Point-of-Care testing. Research interests include the characterization of the molecular basis of inherited disorders, genotype-phenotype correlations, and development of novel molecular diagnostic tools.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Developmental Biology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Bioengineering
Professor, Genetics
Professor (By courtesy), Biology (School of Humanities and Sciences)
Research InterestOur research is focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We study mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We study a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis.
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Academic Appointments Clinical Associate Professor, Surgery - General Surgery
Member, Stanford Cancer Institute
Clinical Focus- GI Oncology
- Rectal Cancer
- Colon and Rectal Surgery
Research InterestMultimodality treatment of rectal cancer Sphincter preserving procedures for rectal cancer Laparoscopic colon and rectal surgery Surgical education
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Academic Appointments Postdoctoral Research fellow, Stanford Cancer Institute
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Academic Appointments Associate Professor, Genetics
Member, Stanford Cancer Institute
Research InterestEvolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species
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Academic Appointments Assistant Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
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Academic Appointments Associate Professor, Medicine - Blood & Marrow Transplantation
Member, Stanford Cancer Institute
Clinical Focus- Blood and Marrow Transplant
- Blood and Marrow Transplantation
- Hematology
Research InterestTransplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.
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Academic Appointments Professor - Med Center Line, Cardiothoracic Surgery - Thoracic Surgery
Member, Stanford Cancer Institute
Clinical Focus- Thoracic Oncology
- Thoracic Cancers - Thoracic Surgery
- Thoracic Surgery
Research InterestIn clinical research, Dr. Shrager has been an innovator studying outcomes in a variety of areas within Thoracic Surgery including: parenchyma-sparing operations and minimally invasive resections for lung cancer, transcervical thymectomy for myasthenia gravis, and surgical treatment of emphysema. In the lab, Dr. Shrager is focused on the impact of disease states upon the diaphragm. His group published the seminal paper (NEJM) describing diaphragm atrophy assoc'd with mechanical ventilation.
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Academic Appointments Assistant Professor, Health Research & Policy - Epidemiology
Member, Stanford Cancer Institute
Research InterestGenetic epidemiology; cancer epidemiology; ovarian, breast, and prostate cancer.
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Academic Appointments Professor, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Sarcoma
- Medical Oncology
- New Drug Studies
Research InterestResearch Interests: cancer pharmacology, mechanisms of resistance to anticancer drugs, regulation and function of MDR1 and tubulin genes, clinical trials of modulation of drug resistance, general oncology, Phase I trials of new drugs, gene expression profiling of cancers
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Academic Appointments Associate Professor - Med Center Line, Neurosurgery
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Neurological Surgery
- Neurosurgery
Research InterestMy research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII
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Academic Appointments Professor, Molecular & Cellular Physiology
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestResearch in the Smith Laboratory addresses basic mechanisms and and disorders of brain function. Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex.
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Academic Appointments Professor, Genetics
Member, Bio-X
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Research InterestWe are presently in an omics revolution in which genomes and other omes can be readily characterized. Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans. 1) Transcriptomes To annotate genomes, we developed RNA sequencing for annotation the yeast and human transcriptomes. We discovered that the eukaryotic transcriptome is much more complex than previously..
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Academic Appointments Professor - Med Center Line, Surgery - General Surgery
Member, Stanford Cancer Institute
Clinical Focus- GI Oncology
- Liver Cancer
- Liver Cancer - Surgery
Research InterestThrough a 3 pronged comprehensive program: translational and clinical research, early detection and treatment, and promoting education, awareness and immunization, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Our current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.
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Academic Appointments Professor, Electrical Engineering
Member, Bio-X
Member, Stanford Cancer Institute
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Academic Appointments Clinical Assistant Professor, Radiation Oncology - Radiation Therapy
Member, Stanford Cancer Institute
Clinical Focus- Radiation Oncology
- Radiation Oncology
- Radiosurgery
Research InterestMy clinical and research interests focus on the development of new radiation techniques involving stereotactic radiosurgery and radiotherapy for the treatment of malignant and benign tumors of the brain and spine, as well as functional disorders such as trigeminal neuralgia.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Radiology - Diagnostic Radiology
Member, Stanford Cancer Institute
Clinical Focus- Diagnostic Radiology
- Radiology
- abdominal imaging and uroradiology
Research InterestStudies include development and preliminary clinical evaluation of advanced techniques for ultrasonic imaging and tissue characterization. A number of studies are ongoing involving advanced techniques of magnetic resonance imaging and spectroscopy with application to the GU tract.
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Academic Appointments Professor, Psychiatry & Behavioral Science - Psychosocial
Member, Stanford Cancer Institute
Clinical Focus- Psychiatry
- Psychiatry, Child and Adolescent
- Medical Director, Stanford Center for Integrative Medicine
Research InterestDr. Spiegel's research program involves mind/body interactions, including cancer progression, the response to traumatic stress, and the effect of hypnosis on the perception of pain and anxiety.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Radiology - Diagnostic Radiology
Member, Stanford Cancer Institute
Member, Bio-X
Professor (By courtesy), Electrical Engineering
Research InterestMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.
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Academic Appointments Professor, Biochemistry
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestThe general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement and changes in cell shape.
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Academic Appointments Associate Professor - Med Center Line, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Urologic Oncology
- Bladder Cancer
- Bladder Cancer - Medical Oncology
Research InterestClinical interests: general oncology, genito-urinary malignancy Research interests: conducting clinical trials in advanced prostate cancer, bladder cancer and renal cell carcinoma
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Academic Appointments Professor (Research), Medicine - Stanford Prevention Research Center
Member, Stanford Cancer Institute
Professor (Research), Obstetrics & Gynecology
Research InterestMarcia Stefanick, Ph.D a Professor of Medicine at the Stanford Prevention Research Center, (SPRC) and Professor of Obstetrics and Gynecology, Stanford University School of Medicine. Dr. Stefanicks research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. Her work on the effects of menopausal hormones on cardiovascular and other health outcomes in mostly healthy postmenopausal women (in the Womens Health Initi..
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Academic Appointments Professor Emeritus, Medicine - Oncology
Emeritus Faculty, Acad Council, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Breast Cancer
- Breast Cancer - Medical Oncology
- Oncology
Research InterestLaboratory and clinical research in breast cancer ; Normal and abornal differentiation and growth
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Academic Appointments Associate Professor, Biochemistry
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestWe study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.
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Academic Appointments Professor, Medicine - Immunology & Rheumatology
Member, Stanford Cancer Institute
Clinical Focus- Immunology and Rheumatology
- Rheumatology
Research InterestMechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.
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Academic Appointments Associate Professor, Urology
Member, Bio-X
Member, Stanford Cancer Institute
Associate Professor, Genetics
Research InterestMy lab focuses on understanding the molecular mechanism of transcription factors that govern the transformation of normal mammalian cells to a neoplastic state. We are especially interested in the action of the nuclear hormone receptors and the interactions between the receptors and other signaling pathways in related human disorders.
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Academic Appointments Assistant Professor, Otolaryngology (Head and Neck Surgery)
Member, Stanford Cancer Institute
Clinical Focus- Cutaneous (Dermatologic) Oncology
- Head and Neck Cancer
- Thyroid Neoplasms
Research InterestMy laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells.
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Academic Appointments Professor, Chemical Engineering - Chemical Engineering Operations
Professor, Bioengineering
Member, Bio-X
Member, Stanford Cancer Institute
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Academic Appointments Associate Professor (Research), Pediatrics - Cancer Biology
Member, Stanford Cancer Institute
Member, Bio-X
Member, Child Health Research Institute
Clinical Focus- Pediatric Hematology-Oncology
- Ewing's sarcoma
- Osteosarcoma
Research InterestOur laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer. Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor - Med Center Line, Dermatology
Member, Stanford Cancer Institute
Clinical Focus- Cutaneous (Dermatologic) Oncology
- Pigmented Skin Lesions
- Melanoma
Research Interest1) Early detection of melanoma through enhanced screening and professional and public education to improve melanoma awareness. 2) Chemoprevention of melanoma and nonmelanoma skin cancers in high-risk groups. 4) Epidemiologic and sociodemographic aspects of melanoma. 4) National dermatologist liaison to the ECOG Melanoma Committee and Co-founder/Co-Director of the Melanoma Prevention Working Group, an interdisciplinary Intergroup collaboration dedicated to melanoma control and prevention
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Academic Appointments Associate Professor - Med Center Line, Surgery - Pediatric Surgery
Member, Stanford Cancer Institute
Member, Bio-X
Member, Child Health Research Institute
Associate Professor - Med Center Line, Pediatrics
Clinical Focus- Surgery, Pediatric
- Pediatric Surgery
Research InterestCurrent research interests include mesenchymal stem cell biology, clonal isolation of mesenchymal progenitors, signaling pathways for maintenance of potency and committment to differentiation. Additional areas of ongoing study are the mechanisms of liver regeneration. Interests include local and humoral cellular components of liver repair and regrowth; and the requisite cellular signaling mechanisms of liver stem cell biology.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
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