Cancer Institute A national cancer institute
designated cancer center
Profile http://med.stanford.edu/profiles/cancer/researcher/Florette_Hazard/
Email this profile
Portrait View Larger

Florette K. Gray Hazard

Academic Appointments

  • Assistant Professor of Pathology and of Pediatrics at the Stanford University Medical Center

Key Documents

Contact Information

  • Clinical Offices
    Department of Pathology 300 Pasteur Dr L235 MC 5324 Stanford, CA 94305
    Tel Work (650) 723-5252 Fax (650) 725-6902
  • Academic Offices
    Personal Information
    Email Tel (650) 725-5189 Tel (650) 723-7211
    Alternate Contact
    Krista Tanquary Administrative Assistant Tel Work 650-721-1618
    Not for medical emergencies or patient use

Bio

Clinical Focus

  • Anatomic/Clinical Pathology
  • Pediatric Pathology

Academic Appointments

Administrative Appointments

  • Director, Pediatric Surgical Pathology (2008 - present)

Professional Education

Medical Education: Georgetown University DC (2002)
Fellowship: Stanford Hospital and Clinics CA (2007)
Residency: Stanford Hospital and Clinics CA (2006)
Internship: Stanford Hospital and Clinics CA (2003)
Board Certification: Pediatric Pathology, American Board of Pathology (2011)
Board Certification: Pediatric Pathology, American Board of Pathology (2011)
View All 14

Research & Scholarship

Current Research and Scholarly Interests

My scholarly pursuits are primarily focused on the study of death and disease in the pediatric population. Most notably to characterize pediatric tumor pathology, evaluate abnormalities of the juvenile reproductive system, demonstrate the histologic and ultrastructural changes of metabolic disorders on specific organs, and elucidate new scientific techniques to aid in the study of childhood disease.

1. Ovarian Surface Epithelial Neoplasms:
Ovarian cancer is the fifth most common cause of malignancy in adult women; with those involving the surface epithelium of the ovary being the most common. In stark contrast, ovarian neoplasms account for approximately 1% of all childhood malignancies with those affecting the epithelium being extraordinarily rare. It is partially due to their low frequency that little is known about the overall incidence, histologic subtypes, optimal treatment strategies, and natural history of ovarian surface epithelial neoplasms in children.

2. Liver Pathology in Mitochondrial DNA Depletion Syndrome:
Mitochondrial disorders are rare causes of childhood disease and dysfunction. Syndromes caused by depletion of mitochondrial DNA (mtDNA) are exceptionally rare, but can often cause devastating outcomes. These depletion syndromes are caused by anomalous mtDNA or nuclear DNA encoding for mitochondrial proteins resulting in a quantitative reduction in mtDNA and abnormal oxidative phosphorylation. To date, three genes have been implicated in this process MPV17, polymerase gamma, and deoxyguanosine kinase. In neonates, these abnormalities most often manifest with hepatic and neurologic dysfunction; the hepatocerebral phenotype. Recognition of the clinical signs and symptoms of mitochondrial DNA depletion coupled with the histologic and ultrastructural features can result in early diagnosis and optimal treatment.

3. Liver Explant Pathology In Argininosuccinate Lyase Deficiency:
Argininosuccinate (ASA) lyase deficiency is the second most common urea cycle disorder in the pediatric population. It manifests in either a neonatal or late onset form with seizures, lethargy, and often hyperammonemia. Due to the risk of cognitive impairment, children are closely followed by monitoring serum ammonia levels and treated with arginine supplementation, dietary restriction, and recently liver transplantation. Characterization of the histologic features of livers in children with ASA lyase deficiency will aid pathologists in providing prompt diagnoses and allow clinicians to impart early therapy before the onset of life threatening complications and cognitive impairment.

4. Tissue Microarray Analysis of Small Volume Cellular Suspensions:
The use of small volume tissue samples in tissue microarray analysis has been plagued by inefficiency and poor reproducibility. Therefore, tissue samples such as cerebrospinal fluid, pleural fluid, bone marrow aspirates, and fine needle aspirates are often excluded from scientific research. A new technique developed by a team of researchers at Stanford University School of Medicine has made utilization of these low volume tissue samples possible. In fact, this technique can be used to establish diagnoses and confirm other ancillary testing results, such as gene expression arrays.

Teaching

Courses

2013-14

Publications

Publications

Publication tag cloud

Publication Topics

View All 12

Stanford Medicine Resources:

Footer Links: