Cancer Institute A national cancer institute
designated cancer center
Profile http://med.stanford.edu/profiles/cancer/researcher/James_Swartz/
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James Swartz

Academic Appointments

  • James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 723-5398
    Administrator
    Andrea Hubbard Administrative Associate Tel Work (650) 736-1807

Bio

Using and Understanding Cell-Free Biology

Swartz Lab General Research Focus:

The current and projected research in the Swartz lab balances basic research in microbial metabolism, protein expression, and protein folding with a strong emphasis on compelling applications. The power and versatility of cell-free methods coupled with careful evaluation and engineering of these new systems enables a whole new range of applications and scientific investigation. Fundamental research on: the mechanisms and kinetics of ribosomal function, fundamental bioenergetics, basic mechanisms of protein folding, functional genomics, and metabolic pathway analysis is motivated by a variety of near- and medium term applications spanning medicine, energy, and environmental needs.

Swartz Lab Application Focus:

In the medical area , current research addresses the need for patient-specific vaccines to treat cancer. Particularly for lymphomas, there is a strong need to be able to make a new cancer vaccine for each patient. Current technologies are not practical for this demanding task, but cell-free approaches are rapid and inexpensive. We have already demonstrated feasibility in mouse tumor challenge studies and are now expanding the range of applications and working to improve the relevant technologies. Experience with these vaccines has also suggested a new and exciting format for making inexpensive and very potent vaccines for general use.

To address pressing needs for a new and cleaner energy source, we are working towards an organism that can efficiently capture solar energy and convert it into hydrogen. The first task is to develop an oxygen tolerant hydrogenase using cell-free technology to express libraries of mutated enzymes that can be rapidly screened for improved function. Even though these are very complex enzymes, we have produced active hydrogenases with our cell-free methods. We are now perfecting the screening methods for rapid and accurate identification of improved enzymes. After these new enzymes are identified, the project will progress toward metabolic engineering and bioreactor design research to achieve the scales and economies required.

To address environmental needs, we are developing an improved water filters using an amazing membrane protein, Aquaporin Z. It has the ability to reject all other chemicals and ions except water. We have efficiently expressed the protein into lipid bilayer vesicles and are now working to cast these membranes on porous supports to complete the development of a new and powerful water purification technology. The same lessons will be applied toward the development of a new class of biosensors that brings high sensitivity and selectivity.

Academic Appointments

Honors and Awards

  • James H. Clark Professor in the School of Engineering, Stanford University (2008)
  • The James Bailey Award, Soc for Biol. Eng. (Am Inst. For Chem. Eng.) (2007)
  • Opening Keynote Speaker, Recent Advances in Ferm Tech (RAFT VII) (2007)
  • Keynote Lecture, 20th Meeting for the European Society for Animal Cell Tech, Dresden, Germany (2006)
  • Member, National Academy of Engineering (NAE) (2006)
  • Leland T. Edwards Professor in the School of Engineering, Stanford University (2006)
View All 20honors and awards of James Swartz

Boards, Advisory Committees, Professional Organizations

  • Member, National Academy of Engineering (2013 - present)

Professional Education

PhD: Massachusetts Institute of Technolog (1978)
ScD: MIT, Biochemical Engineering (1978)

Teaching

Courses

2013-14

Prior Year Coursescourses of James Swartz

Postdoctoral Advisees

Ingmar BuerstelIsis Trenchard

Publications

Publications

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Publication Topics

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