Professional Overview
Honors and Awards
- Searle Scholar Award, Kinship Foundation (2001)
- Beckman Young Investigator Award, Beckman Foundation (2001)
- Sidney Kimmel Award in Cancer Research, Sidney Kimmel Foundation (2001)
- Burroughs-Welcome Career Awards in Biomedical Research, Burroughs-Welcome Fund (1998)
Professional Education
| Ph.D.: | University of Colorado, Boulder, Biochemistry (1993) |
| B.S.: | Nanjing University, PR China, Biochemistry (1987) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
We study the molecular and cellular mechanisms that control mitosis and cytokinesis in normal cells and their dysregulations that lead to aneuploidy and genomic instability in tumor cells. The current focus is on the cell cycle regulatory circuits consisting of kinases and ubiquitin ligases. In addition, we investigate the assembly, dynamics and function of mitotic structures. We use a combination of genomics, cell biology, biochemistry, and molecular genetics in mammalian cells.
Publications
- Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science. 2008; (5883): 1655-8
- DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008; (2): 255-67
- Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol. 2008; (1): 65-78
- RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. Proc Natl Acad Sci U S A. 2008; (36): 13415-20
- Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope. J Cell Biol. 2007; (4): 611-7
- HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J Cell Biol. 2006; (6): 879-91
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