Anne Brunet
Academic Appointments
- Associate Professor, Genetics
- Member, Bio-X
- Member, Stanford Cancer Institute
Key Documents
Professional Overview
Honors and Awards
- Senior Scholar Award, Ellison Medical Foundation (2009-2013)
- Junior Investigator Award, California Institute for Regenerative Medicine (CIRM) (2008-2013)
- Innovation in Aging Research Award, Pfizer/American Association for Aging Research (2005-2007)
- Klingenstein Fellow, The Esther A. & Joseph Klingenstein Fund (2005-2008)
- Alfred P. Sloan Fellow, Sloan Foundation (2006-2008)
- Glenn Award, The Glenn Foundation for Medical Research (2007)
Professional Education
| B.Sc.: | Ecole Normale Superieure, Paris, Molecular Biology (1992) |
| Ph.D.: | University of Nice, France, Cell Biology (1997) |
| Postdoctoral fellow: | Harvard Medical School, Neuroscience (2003) |
Postdoctoral Advisees
Berenice Benayoun, Lauren Booth, Itamar Harel, Chi-Kuo Hu, Salah Mahmoudi, Elena Mancini, Travis Maures, Marlon Stoeckius, Ashley Webb
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
The overarching goal of our lab is to understand the genetic mechanisms of aging and longevity. Aging is a highly plastic process regulated by a combination of genetic and environmental factors.
We have a long-standing interest in the genetic pathway that connects insulin to FOXO transcription factors, a central pathway to regulate lifespan from worms to humans. We use a combination of genetic, molecular, and cellular approaches to analyze the regulation and importance of FOXO transcription factors, and more generally 'longevity genes' in mammals. We are particularly interested in the role of longevity genes in the maintenance of the pool of adult neural stem cells and intact cognitive function during aging. We also use ultra-high throughput sequencing technologies to study epigenetic changes and transcriptional networks during aging.
In parallel, our goal is to identify novel longevity genes using short-lived animal models. Our lab uses unbiased approaches in the nematode C. elegans to identify novel pathways that control organismal longevity, particularly in response to dietary restriction. We are particularly interested in the role of chromatin modifiers in the regulation of lifespan and metabolism.
Finally, we are developing the extremely short-lived African killifish N. furzeri as a new vertebrate model for aging studies. We are taking advantage of this fish to explore the genetic architecture of longevity in vertebrates.
Publications
- Bridging the transgenerational gap with epigenetic memory. Trends Genet. 2013; (3): 176-86
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat Cell Biol. 2013
- FOXO flips the longevity SWItch. Nat Cell Biol. 2013; (5): 444-6
- Aging and reprogramming: a two-way street. Curr Opin Cell Biol. 2012; (6): 744-56
- Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011; (6): 878-92
- Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011; (7373): 365-71
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