Cancer Institute A national cancer institute
designated cancer center
Email this profile

Dean W. Felsher

Academic Appointments

  • Professor of Medicine (Oncology) and of Pathology

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Tel (650) 498-6000
    Alternate Contact
    Leslie Quiroz Tel Work 650-725-6454


Academic Appointments

Honors and Awards

  • Honors, University of Chicago (1985)
  • Emil Bogen Award, University of California, Los Angeles (1992)
  • Physician Post-Doctoral Award, Howard Hughes Medical Institute (1997-1999)
  • Esther Ehrman Faculty Scholar Award, Stanford University (2000-2003)
  • Charles Carrington Prize, Stanford University (2002)
  • Clinical Investigator Award, Damon Runyon Foundation (2003-2008)
View All 9honors and awards of Dean Felsher

Professional Education

MD PhD: UCLA, Medicine/Molecular Biology (1992)
BS: University of Chicago, Chemistry (1985)

Research & Scholarship

Current Research and Scholarly Interests

My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation. Thus, even though cancer is a multi-step process, the inactivation of one oncogene can be sufficient to induce tumor regression. Now, I am using these model systems to address three questions:

1. How do oncogenes initiate tumorigenesis?
2. How does oncogene inactivation cause tumor regression?
3. How do tumors escape dependence on oncogenes?






Publication tag cloud

Publication Topics

View All 107

Stanford Medicine Resources:

Footer Links: