Cancer Institute A national cancer institute
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Edgar Engleman

Academic Appointments

  • Professor of Pathology and of Medicine (Immunology and Rheumatology)

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Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 723-7960

Bio

Academic Appointments

Research & Scholarship

Current Research and Scholarly Interests

Our research is directed at understanding the role of the cellular immune system in cancer and other life threatening conditions and in evaluating the potential to manipulate immune cells for the treatment of these diseases. We have been particularly interested in dendritic cells (DC) and our “first generation” methods for isolating and arming human DC with tumor antigens provided the basis for the Sipuleucel-T (aka Provenge) vaccine that was approved by the FDA in 2010 for the treatment of advanced prostate cancer. More recently, the lab has been studying functionally distinct DC populations, including DC that promote tumor formation and metastases, as well as DC that can induce anti-tumor immunity. We are using genetically engineered mouse models to probe the interactions between tumors and the immune system with the goal of identifying the key cellular and molecular events that lead to tumor elimination or tumor tolerance. We are also using these models to investigate new immunologic approaches to cancer treatment. Although the majority of our studies are performed in mouse models, we also study human tissues and cells, and sometimes perform clinical trials to test therapeutic strategies that have shown promise in our animal models.

Teaching

Courses

2014-15

Prior Year Coursescourses of Edgar Engleman

Graduate and Fellowship Program Affiliations

Publications

Publications

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