Cancer Institute A national cancer institute
designated cancer center
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Zijie Sun

Academic Appointments

  • Professor of Urology

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Academic Appointments

Research & Scholarship

Current Research and Scholarly Interests

Our laboratory is investigating the molecular mechanisms of transcription factors that govern the transformation of normal mammalian cells to a neoplastic state. Many of our studies focus on functional analyses of cell signaling and steroid hormone action in development and oncogenesis. We use targeted conditional and inducible mouse models and other cellular and molecular approaches to uncover gene-expression and genomic and epigenetic alteration that occur during tumor development and progression. Specifically, we are investigating the biological significance of androgen, Wnt, and PI3K signaling pathways in prostate development and tumorigenesis. The central goals of our ongoing work are to further dissect these cellular signaling pathways that regulate oncogenic transformation in tumor initiating cells in order to develop novel therapeutics to target these tumor cells.




Graduate and Fellowship Program Affiliations



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