Daniel Herschlag
Academic Appointments
- Professor, Biochemistry
- Member, Bio-X
- Member, Stanford Cancer Institute
- Professor (By courtesy), Natural Sciences Cluster - Chemistry
- Professor (By courtesy), Chemical Engineering
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-9442Administrative Contact Mary Boyer Administrative Associate Email Tel Work 650-723-6242
Professional Overview
Administrative Appointments
- Senior Associate Dean of Graduate Education and Postdoctoral Affairs, School of Medicine (2011 - present)
Honors and Awards
- William Rose Award, ASBMB (2010)
- Fellow, AAAS (2005)
- Merit Award, NIH (2002)
- Cope Scholar Award, ACS (2000)
- Established Investigator, AHA (1998-2002)
- Pfizer Award for Enzyme Chemistry, ACS (1997)
Internet Links
Scientific Focus
Current Research Interests
Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes. Comparing and contrasting the behavior of RNA and protein systems highlights the unique features of these biological macromolecules and helps elucidate principles of folding and catalysis that may be fundamental to both class of functional macromolecules. Toward these ends, many biochemical and biophysical techniques are employed, both within the lab and through multiple collaborations. Finally, we are also involved in collaborative work with Pat Brown's lab aimed at unraveling the global logic and organization of RNA processing and organization. More detailed descriptions are available from our lab home page.
Publications
- Fundamental Challenges in Mechanistic Enzymology: Progress toward Understanding the Rate Enhancements of Enzymes. Biochemistry. 2013
- Ground state destabilization from a positioned general base in the ketosteroid isomerase active site. Biochemistry. 2013; (6): 1074-81
- Structural ensemble and microscopic elasticity of freely diffusing DNA by direct measurement of fluctuations. Proc Natl Acad Sci U S A. 2013; (16): E1444-51
- A role for a single-stranded junction in RNA binding and specificity by the Tetrahymena group I ribozyme. J Am Chem Soc. 2012; (4): 1910-3
- Electrostatics of nucleic acid folding under conformational constraint. J Am Chem Soc. 2012; (10): 4607-14
- Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study. RNA. 2012; (6): 1222-9
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