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Christos E. Constantinou

Academic Appointments

  • Associate Professor of Urology, Emeritus

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Bio

My major interest is concentrated in the characterization of the control mechanisms associated with the neuromuscular function in the urinary transport system. As a biomedical engineer I focused on the development of appropriate principles and methods essential in clinical diagnosis and basic investigations. In the process we developed novel instrumentation and algorithms to evaluate urinary tract function in both clinical cases as well as under experimental conditions in human and animal models. As a non-clinical member of the faculty in Urology I pursued investigations involving the mechanism of continence, its maintenance and the role of the pelvic floor. In this capacity I was responsible in organizing the first clinical Urodynamics lab at Stanford for the diagnosis of function in patients scheduled for surgical or pharmacological treatment and ultimately assessed the impact of surgery in prospective clinical studies. In doing so I incorporated ultrasound and MRI imaging and image processing to extract biomechanical parameters involved in the voluntary and reflex neuromuscular function. In addition we developed and patented devices equipped with biosensors to evaluate function in control subjects. Other than direct in vivo human investigations, we pursued studies in tissue characterization and mapping of the biomechanics of compliance of human prostate and prolapse tissues having developed a piezoelectric system and microscope; currently patent pending. In pursuing this work major interest was place in collaborative work with colleagues from different countries who have come to contribute to Stanford or I worked in their laboratories during sabbatical periods over time. This work has been primarily funded by NIH grants that I initiated as PI; in addition to direct grants from pharmaceutical companies. Projects have been completed or are ongoing with faculties ranging from Japan, Australia and Europe. In addition to laboratory work, I was elected as scientific chairman of congresses and have given many state of the art presentations. Other than medical research endeavors I have taught in the department of Human Biology at Stanford courses related to the study of biological clocks as well as full courses on the ethics involved in use of human experimentation from a historical as well as a contemporary perspective. Currently I am Editor-in-Chief of the Open Journal of Obstetrics and Gynecology, as well as editor in a number of other clinical and biomedical journals.

Academic Appointments

Administrative Appointments

  • Human Biology Program, Stanford University (1979 - 2012)

Honors and Awards

  • Prize in Experimental Urological Research, German Pharma Association (2000)
  • International Prize for Outstanding Contribution to Urology, CE Alken, Swizterland (1977)

Professional Education

PhD: Stanford University, Biomedical Engineering (1973)
MS: Stanford University, Biomedical Engineering (1968)

Patents

  • Omata, Constantinou, Yamaguchi, Usui. "United States Patent 7,615,014 B2 Device for measuring elastic properties of tissue", Nihon University, Japan, Nov 10, 2009

Research & Scholarship

Current Research and Scholarly Interests

My main recent interest is the application of Biomedical Engineering approaches for the clinical visualization and characterization of the static and dynamic properties of pelvic floor function. This extends to ultrasound Imaging and image processing, construction of computer models and biomechanics analysis of pelvic floor function. It is envisioned that these considerations are important constituents of the clinical evaluation of patients with lower urinary tract dysfunction and urodynamics.

Teaching

Publications

Publications

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