Lawrence Leung
Academic Appointments
- Professor, Medicine - Hematology
- Member, Stanford Cancer Institute
Key Documents
Contact Information
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Clinical Offices
Hematology Clinic 875 Blake Wilbur Dr Clinic C MC 5820 Stanford, CA 94305 Tel Work (650) 498-6000 Fax (650) 724-5203Hematology Clinic 875 Blake Wilbur Dr Clinic C MC 5820 Stanford, CA 94305 Tel Work (650) 498-6000 Fax (650) 724-5203
- Academic Offices
Personal Information Email Tel (650) 725-4036Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cancer> Hematology
- Hematology
Administrative Appointments
- Chief of Staff, VA Palo Alto Health Care System (2006 - present)
- Senior Associate Dean for Veterans Affairs, School of Medicine (2006 - present)
Professional Education
| Residency: | New York Hospital NY (1978) |
| Medical Education: | Columbia University, NY USA (1975) |
| Board Certification: | Hematology, American Board of Internal Medicine (1980) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (1978) |
| Board Certification: | Medical Oncology, American Board of Internal Medicine (1981) |
Graduate & Fellowship Program Affiliations
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
Our long-term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on thrombin, the key enzyme in the blood clotting cascade. Using a library of thrombin mutants generated by site-directed mutagenesis, we have mapped the critical functional sites on thrombin for its interactions with its diverse substrates. We are studying a thrombin-activatable carboxypeptidase that plays a key role in the physiologic regulation of thrombinÂ’'s pro-thrombotic and pro-inflammatory properties. Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders.
Publications
- Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem. 2013; (5): 3097-111
- Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma. J Biol Chem. 2011; (45): 39520-7
- Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J Clin Invest. 2011; (9): 3517-27
- Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma. J Biol Chem. 2011; (45): 39510-9
- Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. Arterioscler Thromb Vasc Biol. 2010; (7): 1363-70
- Heparin-induced thrombosis without thrombocytopenia. J Thorac Cardiovasc Surg. 2010; (2): e6-7
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