Cancer Institute A national cancer institute
designated cancer center
Profile http://med.stanford.edu/profiles/cancer/researcher/Stefanie_Jeffrey/
Email this profile
Portrait View Larger

Stefanie S. Jeffrey, MD

Academic Appointments

  • John and Marva Warnock Professor

Key Documents

Contact Information

  • Clinical Offices
    Stanford Women?s Cancer Center 900 Blake Wilbur Stanford, CA 94305
    Tel Work (650) 498-6000 Fax (650) 736-4167
  • Academic Offices
    Personal Information
    Email
    Alternate Contact
    Research Office Tel Work (650) 723-0799
    Not for medical emergencies or patient use

Bio

Clinical Focus

  • Cancer> Breast Cancer
  • General Surgery

Academic Appointments

Administrative Appointments

  • Chief, Surgical Oncology Research, Stanford University (2005 - present)
  • Program Director, Interdisciplinary Breast Fellowship, Stanford University (1999 - 2004)
  • Chief, Breast Surgery, Stanford University (1997 - 2004)

Honors and Awards

  • NASA Space Act Board Award, National Aeronautics and Space Administration (2006)
  • Certificate of Special Congressional Recognition, Congresswoman Anna Eshoo, U.S. House of Representatives, California 14th Congressional District (2004)
  • Stanford Fellow, Stanford University (2002-2004)
  • John and Marva Warnock Faculty Scholar in Cancer Research, Stanford University (2001)
  • Bessie Legarda Memorial Award, Makati Medical Center, Philippines (2000)
  • Cowell Outstanding Faculty Physician Award, Stanford University (1999)
View All 9honors and awards of Stefanie Jeffrey

Professional Education

Internship: UCSF Medical Center CA (1979)
Residency: UCSF School of Medicine CA (1984)
Board Certification: General Surgery, American Board of Surgery (1985)
Medical Education: UCSF School of Medicine CA (1978)
M.D.: UCSF, Medicine (1978)
M.A.: Harvard University, Chemistry (1974)
View All 7

Community and International Work

Research & Scholarship

Current Research and Scholarly Interests

For the past decade, Dr. Jeffrey's lab has performed molecular profiling of cancer cells with the goal of identifying tumor-specific therapies for the personalized treatment of cancer.

She was a member of the collaborative Stanford/Norway team that pioneered the use of DNA microarrays to measure global gene expression in solid tumors, and was involved in the development of the currently accepted classification schema for breast cancer subtypes based on gene expression profiles- such as low and high proliferation luminal, ERBB2(HER2)-overexpressing, and basal-like breast cancers (which then focused attention on triple negative breast cancers). Her laboratory refined RNA amplification techniques and developed expertise in the transcriptional profiling of tiny quantities of tumor tissue and in RNA isolation from formalin-fixed paraffin-embedded samples.

Her research currently involves extracting and profiling circulating tumor cells (CTCs) from blood and bone marrow to shed light on the metastatic process and eventually to help guide selection of appropriate therapies in individual cancer patients. To facilitate this, Dr. Jeffrey and colleagues from the School of Engineering and Genome Technology Center invented a new technology, the MagSweeper, an automated immunomagnetic separation device that isolates live rare cells from blood with high purity and minimal impact on gene expression. Her lab performs high dimensional single cell analyses on CTCs to investigate how transcriptional profiles or mutational status of different CTC populations relate to metastases and drug response, particularly for newer therapies under development or in Phase I/II clinical trials. CTCs being studied include those from patients with cancers of the breast, prostate, lung, pancreas, and liver. Dr. Jeffrey's lab is also funded to perform preclinical testing on patient-derived xenograft models to identify molecular phenotypes of breast cancer that may be targeted by epigenetic pathway inhibitors drugs, working with colleagues at University of Utah to determine how these newer therapies may be best applied to different subtypes of breast cancer.

In the past, Dr. Jeffrey worked with Dr. Robert Mah at NASA Ames Research Center to study multiplex in-vivo physiologic attributes of breast tumors in real-time using a multisensor NASA Smart Probe that she co-developed with Dr. Mah. It is hoped that future studies will associate real-time physiological features with tumor and CTC profiles for intelligent drug selection.

Teaching

Courses

2013-14

Postdoctoral Advisees

Yoshihiro KanoEvelyn Kidess

Graduate and Fellowship Program Affiliations

Publications

Publications

Publication tag cloud

Publication Topics

View All 90

Stanford Medicine Resources:

Footer Links: