Karl Sylvester
Academic Appointments
- Associate Professor - Med Center Line, Surgery - Pediatric Surgery
- Member, Child Health Research Institute
- Member, Bio-X
- Member, Stanford Cancer Institute
- Associate Professor - Med Center Line, Pediatrics
Key Documents
Contact Information
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Clinical Offices
Pediatric General Surgery 780 Welch Rd Ste 206 MC 5733 Palo Alto, CA 94304 Tel Work (650) 723-6439 Fax (650) 724-5577California Pacific Medical Center Women Children's Center San Francisco, CA 94118 Tel Work (888) 637-2762 Fax (650) 724-5344Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information EmailAlternate Contact Francciny Solano Administrative Assistant Email Tel Work 650 723-6439Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Surgery, Pediatric
- Pediatric Surgery
Professional Education
| Board Certification: | Pediatric Surgery, American Board of Surgery (2002) |
| Fellowship: | The Children's Hospital of Philadelphia PA (1997) |
| Fellowship: | Yale - New Haven Hospital CT (2001) |
| Residency: | University of Pennsylvania PA (1999) |
| Internship: | Hospital of the University of Pennsylvania PA (1993) |
| Medical Education: | Jefferson Medical College PA (1992) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
Dr. Sylvester joined the faculty at Stanford as an Assistant Professor in the Department of Surgery and Division of Pediatric Surgery in 2001. As part of his academic appointment, Dr. Sylvester joined The Childrens Surgical Research Program. His interests are in the biology of mesenchymal stem cells (MSC) and their potential use in clinical cellular therapy or as biologics for use in tissue engineering. He is currently examining the similarities in both genotype and phenotype of MSC from both adipose tissue and bone marrow in numerous mouse models.
Dr. Sylvester has also developed an interest in the regenerative processes of the liver, from both a humoral and local stem cell response perspective. He has developed models of both acute and chronic liver injury and is currently exploring the developmental signals and cellular elements that are responsible for liver growth, regrowth and regeneration.
Dr. Sylvester has established NIH funding for his work in the laboratory, in addition he currently holds two competitive research fellowships. He is the recipient of an American College of Surgeons Faculty Research Fellowship, and an American Pediatric Surgical Association Foundation award. His laboratory includes several post-doctoral trainees who have each achieved competitive funding to support their mentored research projects.
Publications
- The surgical management of necrotizing enterocolitis. Clin Perinatol. 2013; (1): 135-48
- Wnt/β-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3. J Biol Chem. 2013
- SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. PLoS One. 2012; (9): e45119
- β-Catenin regulates hepatic mitochondrial function and energy balance in mice. Gastroenterology. 2012; (3): 754-64
- Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011; (10): 1963-76
- Risk factors for parenteral nutrition–associated liver disease following surgical therapy for necrotizing enterocolitis: A Glaser Pediatric Research Network Study [corrected]. J Pediatr Gastroenterol Nutr. 2011; (5): 595-600
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