Cancer Institute A national cancer institute
designated cancer center
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Daniel Jarosz

Academic Appointments

  • Assistant Professor of Chemical and Systems Biology and of Developmental Biology

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 723-8457 Tel (650) 724-8098
    Administrative Contact
    Kathy Johnson Tel Work (650) 724-8098

Bio

Academic Appointments

Honors and Awards

  • Pathway to Independence (K99/R00) Award, National Institutes of Health (2011-present)
  • Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation (2008-2010)
  • Transition School/Early Entrance Program, University of Washington (1996-2001)

Professional Education

Ph.D.: MIT, Biological Chemistry (2007)
B.S.: University of Washington, Chemistry and Biochemistry (2001)

Research & Scholarship

Current Research and Scholarly Interests

Survival in changing environments requires the acquisition of new heritable traits. However, mechanisms that safeguard the fidelity of DNA replication often limit the source of such novelty to relatively modest changes in the genetic code. Thus, the acquisition of new forms and functions is thought to be driven by rare variants that occur at random, and are enriched during times of stress. We have begun to study an intriguing alternative hypothesis: that intrinsic links between protein folding and virtually every biological trait provide multiple avenues through which environmental stress can directly elicit heritable variation that drives evolution, disease, and development.

Our aim is to identify and characterize these mechanisms at the molecular level, integrating our findings to gain insight into the interplay among genetic variation, phenotypic diversity, and environmental fluctuations in complex cellular systems. Much of our work centers on the specific influence of molecular chaperones, proteins that help other proteins fold. Other projects focus on the induction of epigenetic variation that can be passed from one generation to another via self-perpetuating changes in protein conformation. Our work employs multidisciplinary approaches including biochemistry, genome-scale analyses, high-throughput screening methodologies, live cell imaging, microfluidics, and quantitative genetic techniques. Ultimately we seek to not only to understand mechanisms that link environmental stress to the acquisition of biological novelty, but also to identify means of manipulating them for therapeutic benefit and harnessing their power to engineer synthetic signaling networks.

Teaching

Courses

2013-14

Publications

Publications

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Publication Topics

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