Manish J. Butte, MD PhD
Academic Appointments
- Assistant Professor, Pediatrics - Immunology and Allergy
- Member, Child Health Research Institute
- Member, Stanford Cancer Institute
- Member, Bio-X
Key Documents
Contact Information
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Clinical Offices
Pediatric Allergy & Immunology 730 Welch Road Stanford, CA 94305 Tel Work (650) 723-0290Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 721-1324Alternate Contact Julia Middleton Administrative Associate-Fellowship Coordinator Email Tel Work 650-498-6073Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Allergy and Immunology
- Pediatric Allergy/Immun
Administrative Appointments
- Assistant Professor, Pediatrics Immunology & Allergy (2009 - present)
Honors and Awards
- Award, Bio-X Interdisciplinary Award (2010)
- Scholar, SPARK (2010-2011)
- Fellow, American Academy of Pediatrics (2008-)
Professional Education
| Fellowship: | Children's Hospital Boston MA (06/2006) |
| Board Certification: | Allergy and Immunology, American Board of Allergy and Immunology (2005) |
| Residency: | Children's Hospital of Philadelphia PA (06/2003) |
| Ph.D.: | UCSF, Biophysics (2000) |
| Medical Education: | Brown University - School of Medicine RI (06/1996) |
| M.D.: | Brown Univ. School of Medicine, Medicine (1996) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.
Projects in the lab include:
1) Atomic force microscopy of T cells
2) Mechanobiology of biomaterials, cardiac cells, endothelial cells, and cancers
3) Discovery and characterization of new inhibitory pathways of T cells
4) High resolution visualization of receptor and ligands in the T cell immunological synapse
5) Manipulation of single-receptors on T cells to control activation versus tolerance
6) Development of diagnostic tools for immune monitoring and autoimmune diseases (such as Type 1 diabetes and multiple sclerosis)
7) Characterization of self-like antigens and their roles in autoimmunity (in multiple sclerosis and Type 1 diabetes)
Publications
- Real-time GPU-based 3D Deconvolution. Opt Express. 2013; (4): 4766-73
- Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012; (5): e37559
- CD28 costimulation regulates genome-wide effects on alternative splicing. PLoS One. 2012; (6): e40032
- Counting cells with a low-cost integrated microfluidics-waveguide sensor. Biomicrofluidics. 2012; (1): 14115-141154
- Optical planar waveguide for cell counting. Appl Phys Lett. 2012; (4): 43701-437015
- Single molecule labeling of an atomic force microscope cantilever tip. Appl Phys Lett. 2012; (16): 163705
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