Stefanie Jeffrey
Academic Appointments
- Associate Professor - Med Center Line, Surgery - General Surgery
- Member, Bio-X
- Member, Cancer Center
Contact Information
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Clinical Offices
Stanford Comprehensive Cancer Center 875 Blake Wilbur Dr Clinic F Breast Cancer Clinic Stanford, CA 94305-5826 Tel Work (650) 498-6000 Fax (650) 736-4167
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Academic Offices
Personal Information Email Tel (650) 723-0799Administrative Contact Research Administrator Email Tel Work (650) 723-0799Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Cancer > Breast Cancer
- Surgical Oncology
- Breast Surgery
- General Surgery
Administrative Appointments
- Chief, Surgical Oncology Research, Stanford University (2005 - present)
- Program Director, Interdisciplinary Breast Fellowship, Stanford University (1999 - 2004)
- Chief, Breast Surgery, Stanford University (1997 - 2004)
Honors and Awards
- NASA Space Act Board Award, National Aeronautics and Space Administration (2006)
- Certificate of Special Congressional Recognition, Congresswoman Anna Eshoo, U.S. House of Representatives, California 14th Congressional District (2004)
- Stanford Fellow, Stanford University (2002-2004)
- John and Marva Warnock Faculty Scholar in Cancer Research, Stanford University (2001)
- Bessie Legarda Memorial Award, Makati Medical Center, Philippines (2000)
Professional Education
| Board Certification: | General Surgery, American Board of Surgery (1985) |
| Residency: | UCSF School of Medicine, CA (1984) |
| Internship: | UCSF Medical Center, CA USA (1979) |
| Medical Education: | UCSF School of Medicine, CA (1978) |
| A.B.: | Harvard University, Chemistry and Physics (1974) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Community & International Work
Web Site Links
Scientific Focus
Research Interests
As a member of the collaborative team that pioneered the use of cDNA microarrays to study global gene expression in solid tumors, Dr. Jeffrey's lab continues to study breast cancer genomics using DNA microarrays. Her laboratory has refined RNA amplification techniques so that microarray technology may be used for analysis of very small quantities of tumor tissue such as from needle biopsies, and has developed expertise in RNA isolation from formalin-fixed paraffin-embedded samples.
More recently, her research focuses on the metastatic process in cancer. Dr. Jeffrey's lab has developed a robot, the MagSweeper, that isolates and purifies live rare cells from blood with higher capture rates and purity than has been previously possible with commercial technology. Using the MagSweeper, her lab characterizes circulating tumor cell (CTC) populations from the blood of cancer patients. Studies of CTCs at the single cell level are ongoing to evaluate the role of individual CTC phenotypes in the metastatic process and to compare them with cancer stem cells. Her lab also collaborates with Dr. Richard Bruce on other CTC investigations using novel technology developed at the Palo Alto Research Center (PARC).
Dr. Jeffrey works with Dr. Robert Mah at NASA Ames Research Center to study in-vivo physiologic changes in breast tumors using a multisensor NASA Smart Probe that she co-developed with Dr. Mah, eventually correlating physiologic tumor parameters to gene expression profiles and tumor metabolic pathways.
Clinical Trials
Publications
- Focal amplification and oncogene dependency of GAB2 in breast cancer. Oncogene. 2009
- Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A. 2009; (10): 3970-5
- New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. BMC Cancer. 2008: 66
- DNA copy number alterations and expression of relevant genes in triple-negative breast cancer. Genes Chromosomes Cancer. 2008; (6): 490-9
- Cancer biomarker profiling with microRNAs. Nat Biotechnol. 2008; (4): 400-1
Trial Administration