Irene Wapnir

Clinical Focus

• Cancer > Breast Cancer
• Cancer > Breast Cancer > Breast Cancer Clinical Trials
• Breast Cancer
• Breast Cancer - Surgery
• Breast Surgery

Administrative Appointments

• Chief of Breast Surgery, Section of Surgical Oncology (2005 - present)

Honors and Awards

• Protocol Chair Breast Cancer Local Recurrence Trial, NSABP (2006)
• Working Group Breast Committee, NSABP (2000)
• Awards Committee, Assoc Women Surgeons (2004)

Professional Education

Postdoctoral Advisees

Ogori Kalu

Graduate & Fellowship Program Affiliations

• Surgery

Research Interests

Clinical treatment trials in Breast Cancer, especially locally recurrent breast cancer. She is chair of multicenter national trial investigating the optimal systemic treatment for women who develop a local or regional recurrence of breast cancer after mastectomy or lumpectomy. Additinally, Dr. Wapnir is institutional Principal Investigator for National Surgical Adjuvant Breast and Bowel Project (NSABP). Her basic and preclinical research centers on exploring the activity of breast sodium-iodide transporter (NIS) in breast cancer. Translational research protocols elucidating the potential application of NIS-based therapies are ongoing.

Clinical Trials

• Adjuvant Chemotherapy in Treating Women Who Have Undergone Resection for Relapsed Breast Cancer Recruiting
• Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) Recruiting
• Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample Recruiting
• Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer Recruiting
• Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT Recruiting

Publications

• Endogenous NIS expression in triple-negative breast cancers. Renier C, Yao C, Goris M, Ghosh M, Katznelson L, Nowles K, Gambhir SS, Wapnir I. Ann Surg Oncol. 2009; 16 (4): 962-8
• Association of reactive oxygen species levels and radioresistance in cancer stem cells. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF. Nature. 2009; 458 (7239): 780-3
• Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer. Anderson SJ, Wapnir I, Dignam JJ, Fisher B, Mamounas EP, Jeong JH, Geyer CE, Wickerham DL, Costantino JP, Wolmark N. J Clin Oncol. 2009; 27 (15): 2466-73
• Breast cancer brain metastases express the sodium iodide symporter. Renier C, Vogel H, Offor O, Yao C, Wapnir I. J Neurooncol. 2009
• Timing of breast cancer treatments with oocyte retrieval and embryo cryopreservation. Baynosa J, Westphal LM, Madrigrano A, Wapnir I. J Am Coll Surg. 2009; 209 (5): 603-7