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Leonard HerzenbergAcademic Appointments
Appointment
Organization
Emeritus (Active) Professor
Genetics ;
Immunology ;
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Curriculum Vitae PDF
Honors & Awards
Title
Organization
Date(s)
Kyoto Prize in Advance Technology
Inamori Foundation
2006
Prize in Immunology
Novartis Award
2004
Edwin D. Ullman Award
American Association of Clinical Chemistry
2002
Lifetime Servicce Award
AAI
1998
Member
National Academy of Scientists
1982
Administrative Appointments
Title
Organization
Start Year
End Year
Professor
Genetics
1959
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
CIT
Biochemistry/Immunology
1955
AB
Brooklyn College
Biology, Chenistry
1952
Web Site Links
Research/Lab website:
Herzenberg Laboratory Home Page
Research Interests
Dr. Leonore Herzenberg and I maintain jointly functioning laboratory groups. Our focus is on gene regulation in the immune system, development and function of B cell subpopulations, and applications of Fluorescence-Activated Cell Sorting (FACS).
We have been interested for many years in the genetics and development of the immune system in mice. A major tool we have developed to aid us in this work is the Fluorescence-Activated Cell Sorter(FACS), which permits rapid analysis and sorting of millions of viable cells based on fluorescence marking. Recently we have studied gene regulation at the individual cell level using the FACS and either fluorogenic substrates for lac Z (ß-galactosidase) or Green Fluorescent Protein(GFP).
Current Studies include:
1) Redox regulation of gene expression and diseases, such as AIDS, sepsis, and inflammation.
2) Regulation of lymphocyte development, especially B and T cells.
3) Apoptosis in the immune system and in disease processes, such as cancer and infection.
4) Development of multi-parameter FACS (Flow Cytometry) and Scanning Cytometry.
5) The cell biology of AIDS in model systems and patients.
In addition to improving FACS operations with a dedicated group of engineers, computer scientists, programmers, and a physicist, opportunities always exist for technologically oriented students interested in molecular biology and immunology.
We have been interested for many years in the genetics and development of the immune system in mice. A major tool we have developed to aid us in this work is the Fluorescence-Activated Cell Sorter(FACS), which permits rapid analysis and sorting of millions of viable cells based on fluorescence marking. Recently we have studied gene regulation at the individual cell level using the FACS and either fluorogenic substrates for lac Z (ß-galactosidase) or Green Fluorescent Protein(GFP).
Current Studies include:
1) Redox regulation of gene expression and diseases, such as AIDS, sepsis, and inflammation.
2) Regulation of lymphocyte development, especially B and T cells.
3) Apoptosis in the immune system and in disease processes, such as cancer and infection.
4) Development of multi-parameter FACS (Flow Cytometry) and Scanning Cytometry.
5) The cell biology of AIDS in model systems and patients.
In addition to improving FACS operations with a dedicated group of engineers, computer scientists, programmers, and a physicist, opportunities always exist for technologically oriented students interested in molecular biology and immunology.
Publications
- Wang D, Carroll GT, Turro NJ, Koberstein JT, Kovác P, Saksena R, Adamo R, Herzenberg LA, Herzenberg LA, Steinman L "Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium." Proteomics 2007; 7: 2: 180-4 More »
- Atkuri KR, Herzenberg LA, Niemi AK, Cowan T, Herzenberg LA "Importance of culturing primary lymphocytes at physiological oxygen levels." Proc Natl Acad Sci U S A 2007; 104: 11: 4547-52 More »
- Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA "N-Acetylcysteine-a safe antidote for cysteine/glutathione deficiency." Curr Opin Pharmacol 2007; More »
- Tung JW, Heydari K, Tirouvanziam R, Sahaf B, Parks DR, Herzenberg LA, Herzenberg LA "Modern flow cytometry: a practical approach." Clin Lab Med 2007; 27: 3: 453-68 More »
- Yang Y, Tung JW, Ghosn EE, Herzenberg LA, Herzenberg LA "Division and differentiation of natural antibody-producing cells in mouse spleen." Proc Natl Acad Sci U S A 2007; 104: 11: 4542-6 More »
129 publications: view full list
