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The Genetics of Breast and Ovarian Cancer

According to the National Cancer Institute (NCI), the lifetime risk for a woman to develop breast cancer is 12.8 percent or one in eight, while the lifetime risk to develop ovarian cancer is a little greater than 1 percent (1.4 percent, or one in 70).

Approximately 5 percent to 10 percent of breast and ovarian cancers are due to known predisposing genetic factors. This means that the majority of breast and ovarian cancers are, in fact, not inherited. Consider the following:

There are several genetic syndromes associated with an increased risk for breast and/or ovarian cancer that require clinical care by a physician or other healthcare professional. Listed in the directory below are some, for which we have provided a brief overview.

If you cannot find the information in which you are interested, please visit the Online Resources page in this Web site for an Internet/World Wide Web address that may contain additional information on that topic.

The Genetics of Breast and Ovarian Cancer

Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2)

Peutz-Jeghers Syndrome

The Genetics of Breast Cancer

Li-Fraumeni Syndrome

Cowden Syndrome

Ataxia Telangiectasia (A-T)

The Genetics of Ovarian Cancer

Ovarian Cancer and Hereditary Nonpolyposis Colon Cancer (HPNCC)

Basal Cell Nevus Syndrome (Gorlin Syndrome)

Stanford Medicine Resources:

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