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Risk Factors of Lynch Syndrome (HNPCC)

HNPCC is a genetic condition; you are at risk if you or family members have the mutation.

Criteria Determining an HNPCC Family

An International Collaborative Group (ICG) meeting in Amsterdam established criteria for a diagnosis of hereditary nonpolyposis colon cancer (HNPCC), an autosomal dominant cancer genetic syndrome. These criteria are now known as the ICG or Amsterdam criteria and include the following characteristics in a family:

Below are the Revied Bethesda Guidelines for testing colorectal tumors for microsatellite instability (MSI).

  1. Colorectal or uterine cancer diagnosed in a patient how is less than 50 years of age
  2. Presence of synchronous, metachronous colorectal, or other HNPCC-associated tumors, * regardless of age.
  3. Colorectal cancer with the MSI-H ** histology *** diagnosed in a patient who is less than 60 years of age. +
  4. Colorectal cancer diagnosed in one or more first-degree relatives with an HNPCC-related tumor, with one of the cancers being diagnosed under age 50 years.
  5. Colorectal cancer diagnosed in two or more first- or second-degree relatives with HNPCC-related tumors, regardless of age.

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