High-throughput Bioscience Center is newest Cancer Center core facility
The HTBC is the newest core facility of the SCC. The HTBC provides researchers with the ability to run high-throughput chemical and genetic screens of biological systems. Utilizing the HTBC, SCC researchers have the opportunity to discover chemical modulators of oncogenic mechanisms and to identify new therapeutic targets. Supported research activities include the use of: (1) chemical libraries (http://htbc.stanford.edu/compounds.html) for the identification of small molecule modulators of specific biological processes; (2) siRNA (http://htbc.stanford.edu/htmolbio/sirna.html) libraries for targeted gene silencing; and (3) cDNA (http://htbc.stanford.edu/htmolbio/index.html) libraries for in vivo or in vitro protein expression.
A variety of high-throughput instrumentation is also available for SCC researchers, including microplate liquid-handling robots, a high-throughput molecular biology workstation, multi-label microplate readers and a microplate-compatible epi-fluorescence microscope. Reagents include over 130,000 small molecules (http://htbc.stanford.edu/compounds.html) for compound screens; 21,000 siRNA (http://htbc.stanford.edu/htmolbio/sirna.html) pools targeting the entire human genome; and 8000 cDNAs (http://htbc.stanford.edu/htmolbio/cdna.html) for gene expression screens.
All SCC members will be given priority to the screening projects queue.
High-throughput Bioscience Center, administered by James Chen, PhD,
and David Solow-Cordero, PhD
Contact: David Solow-Cordero, PhD (650) 725-6002; e-mail: desolow@stanford.edu
http://htbc.stanford.edu/
For information on Cancer Center Core Facilities, please visit: http://cancer.stanford.edu/research/core/
Posted 09/11/07
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