Cancer Institute A national cancer institute
designated cancer center
 

July 2012 Cancer Institute Bulletin

DIRECTOR’S UPDATE

The Campaign for Stanford Medicine: Phase One of the Campaign aims to raise $1 billion to support priorities within the School of Medicine as well as ongoing construction of the new Stanford Hospital. Approximately $500 million has already been raised. A second Campaign phase, focused on the School of Medicine, is also anticipated. Enhanced cancer research and treatment capacity is a priority of both phases.

Canary Challenge: I urge you all to sign up for the Canary Challenge bicycle ride on September 29. All of the money raised will benefit the Stanford Cancer Institute. If you cannot ride, please contribute what you can to riders trying to meet—and exceed!—their $400 fundraising goal.  You can register at: www.canarychallenge.com

Share Your News: We would very much like to include your accomplishments in future editions of the Bulletin and the SCI Newsletter. Please advise Sr. Communications Manager Michael Claeys (mclaeys@stanford.edu) of any new grants, awards and major publications.

Members and appropriately affiliated staff can join the SCI Bulletin distribution list via this link: https://mailman.stanford.edu/mailman/listinfo/stanford_cancer_center_news

SAVE THE DATES:

Friday & Saturday, July 13 – 14

Celebration of Success in the Treatment of Hodgkin’s DiseaseThe event will commemorate the 50th anniversary of the initiation of the Stanford clinical trials for lymphoma and honor Dr. Saul Rosenberg for 51 years on the Stanford faculty.          

July 13             
What: Symposium of Tribute, featuring special guests
When: 11:30 am – 5:30 pm
Who: Open to all – RSVP requested
Where: LKSC

July 14
What: Patient & Physician Reunion Event
When: 10:00 AM – 2:00 PM
Who: Open to all – RSVP requested
Where: LKSC 
More: Go to the Radiation Oncology website and click on “Brochure”
Contact Alex Orantes for more info and to RSVP

Saturday, September 29th
2ND Annual Canary Challenge Bicycle Ride Benefitting the Stanford Cancer Institute

Where:  Start and finish at Wmware in Palo Alto
Who:     Open to the public.  Stanford-affiliated participants receive discounts for early registration:
              $75 until June 31th
              $100 until Sept 29th
More:   www.canarychallenge.com

FUNDING OPPORTUNITIES

Reliable Cancer Therapies (www.reliablecancertherapies.com) is soliciting applications for innovative, high-impact projects that explore new concepts or new avenues of cancer research that could represent breakthroughs in cancer treatment. The funder encourages applications that seek to apply or develop state-of-the-art technologies, tools, and/or resources for cancer research, including those with potential commercialization opportunities.

Applicants may request a total of up to $5,000,000 for a period of up to 60 months, inclusive of both direct and indirect costs.

Internal Submission Guidelines:

By 4:00 PM Monday, July 9, 2012, please send Denise Baughman one PDF file containing the following items in the order listed below:

1) Title Page
- RFA name: Reliable Cancer Therapy Rediscovering Breakthroughs
- Project title
- Type of Award Mechanism (indicate one):
         1. Previously submitted, reviewed, scored, or rejected grant applications at the level of an R01 or equivalent
         2. New application
- PI: name, appointment, department, address, phone, email
- Co-PI: name, appointment, department, address, phone email

2) Proposal for previously submitted applications:
- Copy of the summary statement 
- Response statement addressing the criticism made in the summary statement
         (the sponsor requests this and limits it to 5000 characters)
- One-page proposal summary

OR

2) Proposal for new applications:
- One- or two-page proposal clearly explaining the question or problem to be addressed, and the approach to its answer or solution

3) Biosketch

All submitted proposals will be reviewed by an ad hoc committee in the Cancer Institute. More detailed information is available from Denise Baughman.

SHARED RESOURCE UPDATES

Animal Tumor Models                                                                             
Yanru Chen-Tsai, PhD, Director

Mouse strain rederivation and embryo/sperm cryopreservation services
All mice that are brought into the SIM1 barrier facility need to be re-derived, except for mice that are directly shipped from the production barrier of Stanford VSC-approved vendors including Charles River Laboratories, Harlan, Taconic, and Jax. We provide services in mouse strain rederivation and embryo/sperm cryopreservation at a low cost. Please see links for more information:
http://med.stanford.edu/transgenic/SIM1Rederivation.html
http://med.stanford.edu/transgenic/EmbryoCryopreservation2.html
http://med.stanford.edu/transgenic/spermfreeze.html

Bioscience Screening Facility                                  
David Solow-Cordero, PhD, Director

The Bioscience Screening Facility (CCSR-0133, http://htbc.stanford.edu) has recently acquired a few copies of the Qiagen Mouse Whole Genome siRNA set V1 for targeted gene silencing of ~17,000 genes.  Contact the facility Director at desolow@stanford.edu if you wish to learn more about performing a whole genome silencing experiment on your mouse cells.  We also have the siARRAY Whole Human Genome siRNA library from Dharmacon.

Human Immune Monitoring Shared Resource                      
Holden Maecker, PhD, Director

The Human Immune Monitoring Center has a redesigned website. New technology pages with detailed information about all of our assays, are accessible from the home page with a single click.  There is also a link to our online database, Stanford Data Miner (http://datamt.net), which integrates HIMC data, across assays and projects, with clinical and demographic data (if available).  The design of this system was recently published (Siebert et al., Journal of Translational Medicine 2012, 10: 62), and the newest release is compatible with CyTOF mass cytometry data, as well as Luminex, flow cytometry phenotyping, and other assays.

Proteomics Shared Resource                                                                             
 
Allis Chien, PhD, Director

Targeted Metabolomics
Quantitative assays for various metabolite groups, including nucleotides, nucleosides, amino acids, saccharides (mono-, di-, tri-), and other custom metabolites upon request.

Tissue Proteomics
Proteomic studies using banked frozen and FFPE tissues.

Small Molecule Formulation Testing
Active ingredient confirmation; Stability testing; Degradation and impurity profiling; Absolute quantitation.

Contact the lab by email or on the web.

Stanford Cancer Center Research Database

SCCRDB has a rich set of data which integrates many resources including: EPIC, STRIDE, specialized databases in surgical pathology and radiation oncology, the Stanford Cancer Registry, and the Social Security Death Index (SSDI).  The database has been used by a variety of researcher to answer diverse questions.

See the SCCRDB website for more information about the database and how to access it.  

KUDOS

Stephen Quake, PhD, member of the Cancer Stem Cells and Molecular Therapeutics programs, and the Lee Otterson Professor in the School of Engineering and Professor of Applied Physics and, by courtesy, of Physics, has been awarded the 2012 Lemelson-MIT Prize in recognition of his inventions. Quake invented a chip-based technology, called microfluidic large-scale integration, capable of making nearly 10,000 simultaneous measurements. The chip is being used in the development of cancer drugs.

 

Robert Tibshirani, PhD, member of the Radiation Biology and Lymphoma programs, and professor of health research and policy (Biostatistics), has won the 2012 Gold Medal of the Statistical Society of Canada (SSC). This award—the SSC’s highest distinction—is given annually to a Canadian statistician making outstanding research contributions to statistical sciences and is intended to honor a leader in the field.

 

Mark Krasnow, MD, PhD, member of the Cancer Biology program and professor of biochemistry, received a Henry J. Kaiser Family Foundation Award for Excellence in Preclinical Teaching.

 

Daniel Herschlag, PhD, member of the Radiation Biology program and professor of biochemistry, received a School of Medicine Award for Outstanding Service to Graduate Students.  

 

Kara L. Davis, DO, Pediatric Hematology/Oncology Instructor, received a St. Baldrick’s Foundation Scholar Award for her project, “Relapse Prediction by Deep Proteomic Single Cell Analysis of Pediatric ALL.”

 

Mark Pegram, MD, Institute member and director of the Breast Oncology Program, has been appointed to Professor of Medicine, effective 5/01/2012.

 

 

Michaela Liedtke, MD, Institute member, has been reappointed to Assistant Professor of Medicine, effective 9/01/2012.  

 

 

 

SCI NEWSLETTER

CANCER PREVENTION INSTITUTE OF CALIFORNIA NEWSLETTER

JULY CANCER SEMINARS

July 3  Cancer Education Seminar Series – Chemotherapy, Radiotherapy
8:00-9:00 am  Cancer Pharmacology I: Chemotherapy
Victor Villalobos, MD, PhD  
Medical Fellow, Oncology
Stanford University School of Medicine
Clinical Cancer Center, Second Floor (cc 2103-2104)
875 Blake Wilbur Drive

July 5  PhD Thesis Defense
3:00-4:00 pm  The Role of Noncoding RNAs PANDA and DINO in the DNA Damage
Tiffany Hung, Graduate Student
Chang Lab
Cancer Biology Program
Munzer Auditorium, Beckman Center

July 9  Stanford Cancer Institute Seminar
12:00-1:00 pm  The Etiological Role and Variable Inheritance of Constitutional Epimutations in Familial Cancer
Megan Hitchins, BSc Hons I, PhD
Senior Lecturer, Faculty of Medicine
Lowy Cancer Research Centre
University of New South Wales
Lokey/SIM 1,G1161

July 10  Cancer Education Seminar Series – Chemotherapy, Radiotherapy
8:00-9:00 am  Principles of Radiation Therapy
Edward Graves, PhD  
Associate Professor, Radiation Oncology, Radiation Physics
Stanford University
Clinical Cancer Center, Second Floor (cc 2103-2104)
875 Blake Wilbur Drive

July 10  Pathology Grand Rounds
12:00-1:00 pm  Anatomic Pathology in the Molecular Era: SMART Precision Diagnostics
Jennifer L. Hunt, MD
Aubrey J. Hough Jr., Endowed Professor 
Chair, Department of Pathology and Laboratory Medicine
University of Arkansas for Medical Sciences
Li Ka Shing, LK 130

July 11  PhD Thesis Defense
3:00-4:00 pm  Reprogramming of Fibroblasts to a Neural Fate
Tommy Vierbuchen, Graduate Student
Khavari Lab
Cancer Biology Program
Munzer Auditorium

July 12  PhD Thesis Defense
1:00-2:00 pm  RNA-mediated Programming of an Active Chromatin Domain
Yul Yang, Graduate Student
Wernig Lab
Cancer Biology Program
Clark Auditorium

July 17  Cancer Education Seminar Series – Chemotherapy, Radiotherapy
8:00-9:00 am  How Cells Die
Max Diehn, MD, PhD  
Assistant Professor, Radiation Oncology
Stanford University
Clinical Cancer Center, Second Floor (cc 2103-2104)
875 Blake Wilbur Drive

July 20  CCSB Seminar Series
7:30-8:30 am  Dissecting Heterogeneity in Cancer
Florian Markowetz, Professor
Cambridge Research Institute, UK
Li Ka Shing, LK 130

July 24  Cancer Education Seminar Series – Chemotherapy, Radiotherapy
8:00-9:00 am  New Approaches in Cancer Immune Modulation
Holbrook Kohrt, MD, PhD  
Instructor of Medicine, Oncology
Stanford University School of Medicine
Clinical Cancer Center, Second Floor (cc 2103-2104)
875 Blake Wilbur Drive

July 31  Cancer Education Seminar Series – Chemotherapy, Radiotherapy
8:00-9:00 am  Cancer Pharmacology II: Targeted Therapies
Joel Neal, MD, PhD  
Assistant Professor of Medicine, Oncology
Stanford University Medical Center
Clinical Cancer Center, Second Floor (cc 2103-2104)
875 Blake Wilbur Drive

You may suggest items for inclusion in the Bulletin at mclaeys@stanford.edu

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