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designated cancer center

Diagnosis and Treatment of Agnogenic Myeloid Metaplasia (AMM)

Agnogenic myeloid metaplasia (AMM), also known as chronic idiopathic myelofibrosis, is a form of cancer that arises in the bone marrow. AMM symptoms are somewhat similar to chronic myelogenous leukemia (CML) but patient lack the genetic defect known to cause CML.

Patients tend to be over 60 years old, and experience an enlarged spleen and anemia as the bone marrow stops making blood and other organs like the liver and spleen attempt to take over blood production.

Stanford Expertise

When you are being treated for cancer you want a physician who is familiar with your particular disease. Yet because AMM is rare it can be difficult to find a doctor who has treated patients with the disease. Our specialists at the Cancer Center not only treat AMM, but are considered some of the world-leaders in treating leukemia and offer the most advanced diagnostic technologies and treatments available today.

A Personalized, Team Approach

Patients with leukemia are evaluated and treated in Stanford's Hematology and Bone Marrow Transplant clinics by a team of world-renowned faculty. We offer state-of-the-art chemotherapy protocols for leukemia and Stanford hematologists have helped develop the National Comprehensive Cancer Network (NCCN) guidelines for the management of hematologic malignancies. Our goal is to improve the survival and quality of life of patients.


AMM can be difficult to distinguish from other leukemias, yet an accurate diagnosis is essential to receive the correct treatment. By putting your care in the hands of the leukemia experts at the Cancer Center, you can be confident in your diagnosis.

Bone Marrow Transplantation

bone marrow transplant is one possible treatment for AMM. The BMT Program at Stanford has been very successful with a history of limited morbidity rates and acute mortality that is well below most published reports.

Advanced Experimental Therapies

Whenever appropriate and beneficial, physicians at the Stanford Cancer Center offer patients access to experimental therapies. For example, they'll participate in clinical trials  that use leading methods of mobilizing stem cells for patients with AMM receiving high-dose chemotherapy.

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